ISOLATION AND CHARACTERIZATION OF A NEW NUCLEOSIDE ANTIBIOTIC, AMIPURIMYCIN SETSUO HARADA and TOYOKAZU KISHI
نویسنده
چکیده
A new antibiotic amipurimycin, active against Pyricularia oryzae in vitro and in vivo, was isolated from the culture filtrate of Streptomyces novoguineensis nov. sp. The antibiotic was purified by a combination of ion-exchange and adsorption chromatography based on its amphoteric water-soluble characteristics. Its molecular formula was estimated to be C2oH27~31N7O8.H2O. Characteristic maxima in the UV spectrum and signals in the PMR and CMR spectra were similar to those of 2aminopurine 9-(~D)-riboside. These findings indicated that amipurimycin is a new nucleoside antibiotic and the first example of a natural product containing 2-aminopurine.
منابع مشابه
ISOLATION AND CHARACTERIZATION OF MILDIOMYCIN, A NEW NUCLEOSIDE ANTIBIOTIC SETSUO HARADA and TOYOKAZU KISHI
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